Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.

Cultured bovine aortic endothelial cells (BAEC) contain renin and angiotensinogen. To examine whether angiotensins are synthesized intracellularly and secreted by these cells, we assayed cell extracts as well as serum-free media of intact confluent BAEC. Angiotensins were identified by their retention time on reverse phase high performance liquid chromatography and direct radioimmunoassay. BAEC...

متن کامل

Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion.

Cultured bovine aortic endothelial cells (BAECs) express the complete renin-angiotensin system and secrete angiotensins. In this study, we examined the adrenergic influence on the secretion of angiotensins from BAECs. Angiotensins were determined by high-performance liquid chromatography and radioimmunoassay. At basal state, BAECs contain angiotensin I, angiotensin II, and angiotensin III at co...

متن کامل

Renin-angiotensin system and unilateral ureteral obstruction

Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...

متن کامل

Functional intracellular renin-angiotensin systems: potential for pathophysiology of disease.

THE RENIN-ANGIOTENSIN SYSTEM (RAS) is a coordinated hormonal cascade playing a major role in cardiovascular, renal, and adrenal homeostasis (4). Derangements in the RAS have been implicated in the pathogenesis of many disease states, including hypertension and of target organ damage related to hypertension, diabetes mellitus, congestive heart failure, and postmyocardial infarction. Recognized f...

متن کامل

Significance of the vascular renin-angiotensin pathway.

THE circulating renin-angiotensin system plays an important role in blood pressure regulation as well as in fluid and electrolyte balance. Its contribution to cardiovascular homeostasis has been well documented in studies that employ pharmacological or immunological inhibitors." Blockade of the renin-angiotensin system using peptide inhibitors or specific antibodies to renin, angiotensin conver...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Circulation Research

سال: 1987

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.60.3.422